Abstract: Drug-induced diabetes mellitus (DIDM) is secondary diabetes caused by drugs, with different influencing factors and complex pathogenesis. Clinical data have shown that a variety of commonly used drugs, including calcineurin inhibitors, glucocorticoids, antihypertensives, lipid-lowering and anti-atherosclerotic drugs, and antipsychotic drugs, can cause DIDM. This article reviews the research on pathogenesis of DIDM in the past years according to the drug category, in an attempt to provide guidance for the prevention and treatment of DIDM.