Abstract: The core value assessment for innovative pharmaceutical projects is the core work of product initiation, product licensing, investment, mergers and acquisitions in pharmaceutical industry. Multi-level analysis of core values of innovative medical projects from the aspects of unmet clinical needs, market capacity, competitive landscape, clinical success rate, data, intellectual property, and the implementation capacity of R & D team can help to evaluate the commercial prospects, innovation quality and the likelihood of future success of these projects, reducing the systematic risk in new drug R & D. The strategies of core value assessment for innovative pharmaceutical projects have been introduced in this paper.