Abstract: Colorectal cancer, one of the most common malignant tumors of the digestive system, is a major public health threat worldwide. At present, the main treatment for colorectal cancer is surgery combined with radiotherapy and chemotherapy, but it is often accompanied by various side effects. At the same time, some natural compounds with good anti-colorectal cancer activity are expected to become new drug candidates for colorectal cancer treatment. AMP-dependent protein kinase (AMPK), a central hub of intracellular energy metabolism, can regulate tumor cell growth and proliferation by inhibiting its downstream target mammalian rapamycin target protein (mTOR). In recent years, more and more studies have shown that some natural products exert their anti-colorectal cancer activity by regulating the AMPK/mTOR pathway. This article focuses on the role of AMPK/mTOR signalling pathway in colorectal cancer with a review of the research progress of anti-colorectal cancer natural products regulating AMPK/mTOR signalling pathway.