细胞外囊泡在肿瘤靶向治疗中的作用及应用

张宁; 谢姝钰; 常国欣; 陈延; 王岩; 张静; 邱宏

细胞外囊泡在肿瘤靶向治疗中的作用及应用

张宁^1,2,3,
谢姝钰^1,2,3,
常国欣⁴,
陈延^1,2,5,
王岩⁴,
张静⁶,
邱宏^1,2,3, ,

1. 中国科学院上海药物研究所糖类药物研究中心, 上海 201203;
2. 中国科学院大学药学院, 北京 100049;
3. 南京中医药大学新中药学院, 江苏南京 210023;
4. 广东药科大学中药学院, 广东广州 510006;
5. 华南理工大学化学与化工学院, 广东省功能分子工程重点实验室, 广东广州 510640;
6. 广州中医药大学青蒿研究中心, 广东广州 510405

基金项目:

上海市浦江人才计划资助项目(No.19PJ1411300)

详细信息

作者简介:
张宁: 邱宏：理学博士，中国科学院上海药物研究所研究员，课题组长，博士生导师；先后获得美国心脏协会（American Heart Association）博士后基金（Postdoctoral Fellowship）、科学家发展基金（Scientist Development Grant），上海市浦江人才计划，上海市海外高层次人才计划和中国科学院百人计划支持。目前担任中国生物化学与分子生物学学会糖复合物分会理事、中国生物工程协会糖生物工程专业委员会委员和中国生化制药工业协会专家委员会委员。2021年起受邀担任国际糖复合物组织官方期刊Glycoconjugate Journal的Associate Editor。2010年毕业于中国科学院上海药物研究所并获博士学位；其后以博士后和Senior Research Associate身份在世界著名糖科学研究机构佐治亚大学复杂碳水化合物研究中心从事科研工作，2019年回国建立课题组从事糖和糖复合物的基础与转化研究。主要研究方向有：1）糖和糖复合物在发育、组织稳态维持和疾病发生、发展中的作用及以此为基础的疾病诊疗手段研发；2）EVs生物学及其在疾病诊疗中的应用；3）适配体筛选及适配体在疾病诊疗中的应用。研究结果先后以通信作者和第一作者发表在Nature Methods、Molecular&Cellular Proteomics、Journal of Biological Chemistry、Acta Pharmaceutica Sinica B和Glycoconjugate Journal等期刊

通讯作者:
邱宏, 博士生导师

中图分类号: R730.5
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出版历程
- 收稿日期: 2022-01-21
- 修回日期: 2022-01-21

Effect and Application of Extracellular Vesicles in Targeted Cancer Therapy

ZHANG Ning^1,2,3,
XIE Shuyu^1,2,3,
CHANG Guoxin⁴,
CHEN Yan^1,2,5,
WANG Yan⁴,
ZHANG Jing⁶,
QIU Hong^1,2,3, ,

1. Carbohydrate-based Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
2. School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China;
3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China;
4. School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China;
5. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;
6. The Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

More Information

Corresponding author:
QIU Hong, 博士生导师

摘要

摘要: 植物细胞、细菌细胞和哺乳动物细胞均可生成和分泌细胞外囊泡，囊泡内含有蛋白质、核酸、脂质和小分子代谢物。在发现早期，细胞外囊泡只被认为是细胞处置细胞废弃物的一种方式，后发现这些囊泡可在不同细胞之间传递活性物质并改变囊泡受体细胞表型。越来越多的研究证实囊泡是细胞间短程和长程通讯的一种新机制，是细胞间通讯的新范式。细胞外囊泡具有广泛的生理病理作用，既可直接用作药物也可作为药物递送载体，还可作为药物靶标和生物标志物。综述植物、细菌和哺乳动物等不同细胞来源的细胞外囊泡在肿瘤靶向治疗中的作用和应用及工程化策略。
- 细胞外囊泡 /
- 肿瘤 /
- 靶向治疗
Abstract: Plant cells, bacterial cells, and mammalian cells can produce and secret extracellular vesicles (EVs) encapsulated with proteins, nucleic acids, lipids, and small molecules. At the very beginning of research on EV, EVs were thought to function solely as a way to dispose cellular waste. Later on, EVs were found to be able to carry and transfer bioactive substances between cells and change the phenotype of the recipient cells. More and more studies have confirmed that EVs are novel mediators for short- and long-range intercellular communication and new pattern of intercellular communication. EVs have broad physiological and pathological effects and can serve as diagnostic biomarkers, drugs, drug targets, and drug carriers. In this paper, we review the effect, application, and engineering strategies of EVs from different sources in targeted cancer therapy.
- extracellular vesicle /
- cancer /
- targeted therapy

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