Abstract: Diabetic cardiomyopathy (DCM) is one of the major complications of diabetes. It is a unique set of heart-specific pathological variables in diabetic patients, independent of hypertensive heart disease, coronary atherosclerotic heart disease, valvular heart disease and other heart diseases. The final progress of DCM can lead to heart failure and death. Therefore, the treatment of DCM has attracted increased attention. The research progress in therapeutic drugs for DCM was reviewed from the aspects of western medicine and traditional Chinese medicine, so as to provide reference for clinical treatment.