Abstract: The accumulation of molecular, cellular and organ damage in the process of aging can induce various diseases, such as cardiovascular, metabolic and nervous system diseases. With the continuous increase of elderly population in recent years, the problems caused by aging are becoming more and more serious, so biomarkers are needed to predict, diagnose and follow up the aging process.Studies have shown that polysaccharides on the surface of proteins are likely to act as the biomarkers. The glycosylation level of protein reflects the real-time state of intracellular and intercellular biological processes, which can provide potential biomarkers for diagnosis and prognosis of multifactor diseases by observing changes in glycosylation level. This article reviews the changes of glycosomics in aging and aging-related diseases, so as to provide ideas for the research on the mechanisms as well as the diagnosis and treatment of diseases.