Abstract: With the maturity of DNA recombination technology and gene cloning technology, gene therapy, a revolutionary medical technology, continues to develop, changing the treatment status of single-gene genetic diseases with new options for tumors, genetic diseases and autoimmune diseases. As of February 2022, 37 gene therapy drugs have been approved worldwide. Through data monitoring and analysis of gene therapy drugs approved for marketing worldwide from 1998 to 2022, including drug names, indications, approval dates, approved countries, companies and other information, the classification of marketed gene therapy drugs and the global research and development status of each drug were analyzed and summarized to provide reference for the research on gene therapy drug development.