Abstract: Compared with the crystalline form, the amorphous form can increase the solubility and dissolution rate of poorly water-soluble drugs. Amorphous pharmaceutical solid has become one of the most effective formulation approaches to enhance the oral bioavailability of poorly water-soluble drugs. A number of preparation methods have been developed to manufacture amorphous drugs. For instance, spray drying and hot melt extrusion have been widely used in pharmaceutical industry to manufacture amorphous drugs in large scales. In recent years, some new technologies have been developed to produce amorphous solid dispersions, including 3D printing, solvent-based electrospinning method, etc.. Different manufacturing methods will significantly affect the physicochemical properties and performances of amorphous pharmaceutical solids. This review outlined and analyzed the most recent advances in the preparation of amorphous pharmaceutical solids, so as to provide reference for the development of amorphous drugs.