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新药研发前沿动态 / 医药领域趋势进展

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曹羽佳, 刘红霞, 何朝勇. 血小板衍生生长因子及其受体与肿瘤发生发展的研究进展[J]. 药学进展, 2023, 47(2): 145-153. DOI: 10.20053/j.issn1001-5094.2023.02.009
引用本文: 曹羽佳, 刘红霞, 何朝勇. 血小板衍生生长因子及其受体与肿瘤发生发展的研究进展[J]. 药学进展, 2023, 47(2): 145-153. DOI: 10.20053/j.issn1001-5094.2023.02.009
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CAO Yujia, LIU Hongxia, HE Chaoyong. Research Progress of Platelet-derived Growth Factors and Their Receptors in Tumor[J]. Progress in Pharmaceutical Sciences, 2023, 47(2): 145-153. DOI: 10.20053/j.issn1001-5094.2023.02.009
Citation: CAO Yujia, LIU Hongxia, HE Chaoyong. Research Progress of Platelet-derived Growth Factors and Their Receptors in Tumor[J]. Progress in Pharmaceutical Sciences, 2023, 47(2): 145-153. DOI: 10.20053/j.issn1001-5094.2023.02.009
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血小板衍生生长因子及其受体与肿瘤发生发展的研究进展

Research Progress of Platelet-derived Growth Factors and Their Receptors in Tumor

    摘要
  • 摘要: 血小板衍生生长因子（PDGF）和血小板衍生生长因子受体（PDGFR）在血管生成及细胞的有丝分裂作用中具有重要作用，并通过多种途径影响肿瘤的生长和转移。综述肿瘤微环境各型细胞中PDGF/PDGFR的表达对肿瘤发生发展影响的研究进展，并总结近年相关药物的临床研究成果，为肿瘤的治疗提供参考。

     

    Abstract: Platelet-derived growth factor (PDGF) and PDGFR (platelet-derived growth factor receptor) play an important role in angiogenesis and cell mitosis, and affect the development and metastasis of tumor in several ways. This review summarizes the advances in research on the effects of PDGF/PDGFR on tumor progression tracking by the cell types in tumor environment, and the clinical research breakthroughs of related drugs in recent years, aiming to provide reference for tumor treatment.

     

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