基于糖谱的体外检测和诊断的临床应用研究进展

Clinical Application of in vitro Detection and Diagnostic Based on Glycan Profiling

摘要: 检测样本中游离及共价连接在糖肽上的寡糖链，构成糖谱。糖谱上寡糖链类型和丰度的变化可能与病理生理改变相关，具重要的诊断价值，并已应用于临床检测。综述糖谱在肿瘤、感染性疾病、自身免疫性疾病、遗传性疾病中的变化，以及糖谱分析在体外诊断中的进展，为糖谱检测的临床应用提供方向。

Abstract: Glycan profile is a collective presentation of free and conjugated oligosaccharides detected in a clinical sample. The changes of glycan profile, which might reflect physiological and pathological changes, have diagnostic value, and have been applied in various clinical settings. This paper reviews the current applications of glycan profile in tumors, infections, autoimmune conditions and genetic diseases, as well as the new development of glycan profiling methods, aiming to provide some new insights for the clinical application of glycan profilebased detection.