Abstract: Liver diseases affect hundreds of millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and treatment. However, with the improvement of the living standards, the prevalence of metabolic liver diseases including non-alcoholic fatty liver disease and alcohol-related liver disease is rising, ultimately leading to more cases of end-stage liver diseases. Gynostemma pentaphyllum, a traditional Chinese medicine, has a long history of clinical use and high safety. As its main medicinal ingredient, gypenosides have been proved to be effective in the treatment of various liver diseases. In this paper, relevant literature reports in recent years were reviewed to summarize the progress of research on the efficacy and mechanism of gypenosides in treating liver diseases, aiming to provide reference for further basic research and clinical application of gypenosides.