Abstract: Uric acid (UA), the end-product of purine metabolism in human, is mainly excreted through the kidneys. With the change of our lifestyles, the incidence of hyperuricemia is getting higher every year. The close relationship between uric acid and cardiovascular disease (CVD) has been recognized from a number of studies. This review summarizes the metabolism of uric acid, the correlation between uric acid and CVD, the potential mechanism of uric acid involvement in CVD, as well as the protective effect of uric acid-lowering drugs on CVD, aiming to provide evidence for related research.