Recent Advances of Nano-immunomodulatory for Reversal of Cold Tumor Microenvironment

Tumor immunotherapy is limited by the immunosuppressive barrier of the cold tumor. With years of efforts for the exploration of the tumor immunosuppressive barrier, nano-immunomodulatory has become the new paradigm of application for precise remodeling of tumors to amplify the effect of cancer treatment. The definition and characteristics of tumor are summarized to illustrate how engineered nanoplatforms break immunosuppressive. Furthermore, the translation and bottleneck of nano-immunomodulatory are discussed for enhanced immunotherapy in cold tumor.