Research Progress of Cell Membrane-Coated Nanomedicines for Cancer Immunotherapy

Immunotherapy revolutionizes the field of cancer therapy. However, the clinical response rate of current immunotherapy is marginal due to poor activation, limited tumor infiltration and low activity of anticancer immune cells. Nanomedicine elicits unique interactions with both cancerous and immune cells, showing great potential in enhancing cancer immunotherapy. Recently, cell membranecamouflage has been extensively explored as a strategy to modulate interactions between nanomedicines and cells involved in anticancer immunity. Given the enormous design space and good biocompatibility of natural and engineered cell membranes, cell membrane-coated nanomedicines have shown great advantages in cancer immunotherapy. Recent advances reveal that cell membrane-coated nanomedicine can enhance cancer immunotherapy by a series of immune response processes including promoting immunogenic cell death of cancerous cells, improving antigen presentation and T cell activation, and increasing recognition and killing of cancerous cells by T cells. Review of these progresses provides reference for further optimization and clinical translation of cell membrane-coated nanomedicines for cancer immunotherapy.