Progress of Research on Anti-tumor Activity of Phenazine and Its Analogs

Phenazine is a class of nitrogen-containing heterocyclic compounds that are widely found in nature. It is derived from the secondary metabolites of soil and marine microorganisms and exhibits important biological activities. Inspired by the natural phenazine active skeleton, the discovery of active lead compounds with novel structures and clear targets is of great value in pharmaceutical research. Progress of research on the structure, antitumor activity and action mechanism of phenazine natural products and their synthetic analogs is summarized, so as to provide reference for the application of phenazine compounds in drug research and development.