Clinical Application of in vitro Detection and Diagnostic Based on Glycan Profiling

Glycan profile is a collective presentation of free and conjugated oligosaccharides detected in a clinical sample. The changes of glycan profile, which might reflect physiological and pathological changes, have diagnostic value, and have been applied in various clinical settings. This paper reviews the current applications of glycan profile in tumors, infections, autoimmune conditions and genetic diseases, as well as the new development of glycan profiling methods, aiming to provide some new insights for the clinical application of glycan profilebased detection.