PET Imaging Study of Coronavirus-related Targets

Molecular imaging technology, as a newly developed non-invasive, in vivo and dynamic clinical diagnosis technology, is the key technology to achieve visualization and integration of diagnosis and treatment in modern medical practice. Among them, positron emission computed tomography (PET), with its ultra-high sensitivity and accuracy in nuclear medicine application, has become the forefront and core molecular imaging technology in current clinical application after decades of development. Its guiding role and important application in clinical diagnosis and treatment provide a practical basis for the research and development of inhibitors and targeting probes of novel coronavirus. The biological and clinical research progress of series of molecular imaging of potential receptors of novel coronavirus, such as human angiotensin converting enzyme and other protein targets, nucleoside receptors and inhibitors, was reviewed, in order to provide reference for the research and development of integrated drugs for the diagnosis and treatment of novel coronavirus.