Combined Application of Induced Pluripotent Stem Cells and Gene Editing Technology in the Research of Inherited Heart Disease

Inherited heart disease is the main cause of malignant arrhythmia and sudden cardiac death, but little is known about its mechanism. Advances in gene editing technology have made it possible to cure inherited heart disease. Research progress in the molecular mechanism of inherited heart disease, induced pluripotent stem cell (iPSC), iPSC-derived cardiomyocyte (iPSC-CM) and gene editing technology were reviewed, with focus on the application of iPSC, iPSC-CM and gene editing technology in establishing human cell models of inherited heart disease and exploring new treatment options.