Research Progress on the Role of Ferroptosis in the Development of Non-alcoholic Steatohepatitis

Ferroptosis refers to cell death induced by lethal accumulation of iron-dependent lipid peroxides. Intracellular iron overload and accumulation of a large amount of reactive oxygen species (ROS) catalyze the peroxidation of unsaturated fatty acids highly expressed on the cell membrane, thereby inducing cell death. Programmed cell death such as autophagy and apoptosis plays an important role in the occurrence and progression of non-alcoholic steatohepatitis (NASH). Research findings show that ferroptosis is directly involved in the development from simple fatty liver to NASH, inhibiting ferroptosis and almost completely inhibiting the occurrence of NASH. This review focuses on whether iron death is involved in the progression of NASH, which is expected to provide new reference for the mechanism research and clinical treatment of NASH.