Research Progress in Long-acting Technology for Delivering Protein and Peptide Drugs

In recent years, protein and peptide drugs have been widely favored by researchers because of their significant advantages in the treatment of diseases. However, these drugs generally have a short half-life, which affects patient compliance. In this paper, combining the pharmacokinetic characteristics of protein/peptide drugs, the progress of long-acting technology for delivering protein and peptide drugs is summarized, including amino acid substitution, site-directed mutagenesis, fusion with other proteins at genetic level, glycosylation, cyclization, polymer conjugation, stapled peptide, new formulation development methods, hoping to be helpful to the drug developers.