Research Progress in the Theory and Clinical Application of Antibacterial PK/PD

Due to the irrational use of antimicrobial agents, bacterial resistance has been increasing year by year. PK/PD study fully considers the relationship among pathogens, hosts and drugs, which reflects the relationship between bactericidal effects and adverse reactions of antibiotics and the change of blood concentration, which is of much value to the development and application of antibiotics. In this paper, the basic theory of PK/PD, related models and clinical applications are reviewed, with an aim to provide a basis for the rational use of antimicrobial agents and the reduction of drug-resistant bacteria.