Research Progress of Voltage Gated Calcium Ion Channel Drugs

Voltage-gated calcium channels (VGCC) are an important type of signal transverter on the cell membrane. It can transform membrane potential into local intracellular calcium ion instantaneous changes, thereby initiating many important physiological activities such as muscle contraction, hormone secretion, nerve transmission and gene expression. Abnormal expression and dysfunction of VGCC are associated with the occurrence of diseases like hypertension, angina pectoris, arrhythmia, pain, epilepsy and Parkinson's disease. In recent years, drugs targeting VGCC have shown good therapeutic effects and minor adverse reactions, with good application prospects. The structure and function of VGCC and the research progress of related drugs are reviewed in order to provide reference for the development of drugs related to VGCC.