Research Progress of Chinese Materia Medicainduced Cardiotoxicity

Drug-induced cardiotoxicity, one of the major safety concerns in the clinical application of drugs, has aroused our wide attention. Currently, there have been standard evaluation systems for cardiotoxicity caused by chemical drugs, however, existing evaluation methods are not fully applicable to Chinese materia medica (CMM)-induced cardiotoxicity, which can be affected by many factors with complex toxicity mechanisms, diverse toxic effects and lack of specific evaluation indicators. The establishment of CMMinduced cardiotoxicity evaluation system has become an important issue, which urgently needs to be solved in the discovery, approval and regulation of new drugs in China. This article reviews the main factors for the cardiotoxicity of CMM, the mechanisms of cardiotoxicity, the general monitoring indicators, and the latest research techniques for cardiotoxicity caused by CMM, which aims to provide reference for the safety evaluation of CMM.