创新链/学科链/研发链/产业链

新药研发前沿动态 / 医药领域趋势进展

MIN Xiangyan, CAO Ning, YAN Yijia, CHEN Zhilong. Research Progress in New Photodynamic Therapy with Padeliporfin[J]. Progress in Pharmaceutical Sciences, 2019, 43(3): 231-237.
Citation: MIN Xiangyan, CAO Ning, YAN Yijia, CHEN Zhilong. Research Progress in New Photodynamic Therapy with Padeliporfin[J]. Progress in Pharmaceutical Sciences, 2019, 43(3): 231-237.

Research Progress in New Photodynamic Therapy with Padeliporfin

  • Photodynamic therapy has been widely used in the treatment of tumors and has broad application prospect. Recent studies have shown that padeliporfin, a water-soluble vascular-targeting photosensitizer can selectively accumulate in tumor cells after intravenous administration and release a large amount of reactive oxygen species upon photoactivation, thereby exerting anti-tumor effect. This drug has been approved in Europe as a treatment for prostate cancer. This review mainly introduced the discovery process, synthetic route, pharmacological action and clinical research progress of padeliporfin, so as to provide reference for further exploration of tumor photodynamic therapy.
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