Research Progress in Mn-based Enzyme Mimics and Nanozyme-RNA Complexes for Regulating Hypoxia

Hypoxia inducible factor (HIF) activates multiple downstream genes through transcription and regulates metabolic reprogramming of tumor cells, thus facilitating tumor cells to adapt to hypoxic stress. Under hypoxia, non-heme oxidases such as HIF-1 prolyl hydroxylase and catalase are depressed. Therefore, it is a new approach for cancer therapy to inhibit the immune escape during tumor progression or inhibit tumor HIF by using Mn-mimics of non-heme dioxygenase. In this article, the research progress in Mn-mimics of HIF prolyl hydroxylase, Mn-based nanozymes and nano-metalloenzyme-siRNA complexes for regulating HIF were reviewed, and the current problems and future development trend were also analyzed and prospected.