Progress in Cerebrovascular Dysfunction Mediated-Vicious Circle of Cognitive Impairment in Alzheimer's Disease

Alzheimer's disease (AD) is a common neurodegenerative disease whose pathogenesis remains unclear. Due to the failure of several molecules targeting amyloid beta(Aβ), the amyloid cascade hypothesis has been challenged. Cerebrovascular dysfunction is a major risk factor for several brain diseases and plays an important role in AD. Consequently, vascular hypothesis of AD has attracted increased attention. Cerebrovascular dysfunction increases the deposition of Aβ and Tau protein in the brain via a variety of pathways to accelerate the progression of AD. Meanwhile, Aβ can induce vascular dysfunction through multiple pathways in AD, which comes into a vicious circle. In this study, the relationship between cerebrovascular dysfunction and AD was reviewed and the strategies to postpone the progression of AD through the improvement of vascular function were summarized, so as to provide reference for clinical treatment.