Immunometabolic Signaling Pathways Based Researches on Non-alcoholic Steatohepatitis and Intervention by Traditional Chinese Medicines

Non-alcoholic steatohepatitis (NASH) is an increasingly common metabolic liver injury worldwide. It is probably caused by various factors including genetic factors and multiple metabolic disorders, although the exact pathogenesis is still unclear. Currently the mainstay treatment of NASH aims at controlling metabolic state and changing lifestyle. However, its long-term compliance is very low, and not applicable to all NASH patients. Traditional Chinese medicines not only have multiple biological functions such as anti-oxidative, anti-inflammatory and lipid-lowering activity, but also show obvious advantages in clinical research with better efficacy and less side effects. This article reviewed the research progress in NASH from the perspective of immune metabolism and its intervention by traditional Chinese medicine, so as to provide new targets and ideas for further study of NASH therapy.