Research Progress in the Regulation of Bile Acids and Bile Acid-activated Receptor on NLRP3 Inflammasome in Intestinal Diseases

Bile acids, vital signaling molecules that play important roles in the regulation of metabolism, immunity and inflammation, are closely associated with intestinal homeostasis. NOD-like receptor protein 3 (NLRP3) inflammasome is a kind of pattern recognition receptor. It can perceive exogenous microorganisms or endogenous danger signals from damaged or dead cells by recognizing pathogenassociated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), so as to regulate intestinal immune process. Studies have shown that there are multiple regulatory patterns between bile acids and NLRP3 inflammasome, which are involved in the maintenance of intestinal homeostasis and regulation of disease. This review summarizes current research advances at home and abroad in the regulation of bile acids and bile acid-activated receptor on NLRP3 inflammasome in intestinal diseases.