Research Progress of ATP-Binding Cassette Efflux Transporters on Blood-Retina Barrier

As an important biological barrier of the eyes, blood-retina barrier(BRB) can regulate the material exchange between blood and retinal tissue, prevent macromolecules and other potentially harmful substances from entering the retina, and maintain the stability of the retinal microenvironment.It can express a variety of efflux and uptake transporters, which play a key role in the uptake of some essential nutrients and the efflux of neurotransmitter metabolites, hormones and drugs.This paper describes the function of BRB, the expression and distribution of related efflux transporters, and the changes of efflux transporters in disease states, providing important information for the development of new drugs for the treatment of retinal diseases and the maintenance of retinal functional health.