Reaserch Progress of Pharmacokinetics of Bispecific Antibody

A bispecific antibody (BsAb) is an engineered antibody that simultaneously binds to 2 different epitopes on one or two antigens. Currently, more than 100 bispecific antibodies are under clinical trials with broad therapeutic applications ranging from cancer to autoimmune diseases. Rapid development of biotechnology has generated various formats to construct bispecific antibodies, which exhibit distinct pharmacokinetic (PK) behaviors of absorption, distribution, metabolism and excretion. Therefore, the in-depth study of the PK behaviors is critical for the rational design of bispecific antibodies. This review summarizes the formats and PK performances of the bispecific antibodies currently under clinical trials, aiming to provide reference for the design of bispecific antibody drugs and their clinical trials.