Progress in Pharmacokinetics of Bio-macromolecules

Bio-macromolecular drugs have developed rapidly in recent years and attracted more and more attention. Compared with traditional small molecule drugs, bio-macromolecules are characterized by large molecular mass, poor permeation across biological membranes, low dosage and easy degradation in vivo, which leads to different pharmacokinetics from traditional small molecule drugs. This paper reviewed the pharmacokinetic characteristics of bio-macromolecular drugs including protein and polypeptide drugs, monoclonal antibody drugs, antibody-drug conjugates and nucleic acid drugs, so as to provide reference for the development of bio-macromolecular drugs and biosimilars.