Drug Interaction and Dose Adjustment Strategy of Tacrolimus in Renal Transplantation Recipients

Different types of rejection may occur after kidney transplantation, and tacrolimus has been used as the primary agent for immunosuppressive therapy. However, individual differences in tacrolimus metabolism are significant; besides, renal transplant recipients are prone to develop fungal infections due to invasive procedures and prolonged immunosuppression, so anti-fungal drugs such as voriconazole are often clinically used in combination with tacrolimus. There is obvious drug interaction between voriconazole and tacrolimus, which may lead to serious adverse drug reactions, therefore, it is necessary to pay special attention to the change in the blood concentration of tacrolimus and adjust the dosage timely. This paper summarizes the necessity and interaction of tacrolimus and voriconazole in renal transplantation recipients, the effects of other drugs on tacrolimus metabolism, and dose adjustment strategy of tacrolimus in kidney transplantation recipients, in order to provide reference for clinical therapeutic regimens.